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Moreover, the most clinically affected tissue in Coq9 R239X mice, the brain, shows a reduction in the levels of total GSH, together with a decrease in the levels and activities of the glutathione reductase (GRd) and glutathione peroxidase 4 (GPx4) enzymes [75]

Thus, an increasing body of evidence suggests that accumulating ROS, dysfunctional mitochondria, and DNA damage play an important role in the aging process

Astragaloside IV prevents obesity-associated hypertension by improving pro-inflammatory reaction and leptin resistance

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Vitam Horm 102:151178

Likewise, excessive iron intake led to reduced expression of MBP, a marker of mature oligodendrocytes, in the hippocampus of nursing piglets [90]