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The level of TMAO in each stage of CKD patients was different (Hu et al., 2022)

The genus alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

2018;50:e12927

If Fukami et al

TMAO can combine with and trigger the ER stress kinase PERK, specifically stimulating the PERK arm of the unfolded protein response (UPR)