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These challenges have led to the development of more stable analogues, improved delivery systems, and increased interest in smaller peptide fragments that retain bioactivity while minimizing these drawbacks 9

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There is no evidence from long-term use in patients with pernicious anemia that cyanocobalamin is carcinogenic

Finally, participants were filtered on relatedness such that no two people shared more than 700 cM identity by descent 37 , which corresponds approximately to the minimal expected sharing between first cousins in an outbred population, resulting in a final GWAS sample size of 15,237