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Splenomegaly is generally not seen in G6PD-deficient individuals

doi: 10.1007/s12011-022-03362-9 206 YangMShenZZhangXSongZZhangYLinZet al

German J

Cambridge, MA, USA: 2021

Specifically, immunotherapy-induced tumor-infiltrating CD8 + T cells produce IFN-, which can enhance FGF2 signaling or upregulate branched-chain amino acid aminotransaminase 1 (BCAT1), enhancing the tumor stemness that confers the cross-tolerance to immunotherapy, chemotherapy and TKIs [131, 132]

Studies demonstrate that PARx can inhibit tumour growth without off-target toxicity in a lung cancer xenograft model
