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doi: 10.1001/jama.2012.8265

The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012

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Bhardwaj V, Kaushik A, Khatib ZM, Nair M, McGoron AJ

[4] [5] Importantly, the PDC catalyzes the same reactions through highly conserved mechanisms in all organisms