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Description
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Kaneko S, Li X
The size of the formulation was 180 nm, with a PDI value of less than 0.3 and a zeta potential of-37.29 mV indicating high stability

10.1007/s11130-011-0216-6 138 MousaA
Maximum accumulation times were set at 200 ms for FTMS and 50 ms for MSn scans

Opiates can be a little easier though, if protocol is followed, and the patient has willingness to proceed