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Within the immune landscape, leptin plays a central role in swaying the differentiation of CD4+ T cells towards a predominantly Th1-centric response (85)

(128) it has also become apparent that the nucleolus plays and important function in maintaining the homeostatic (proteostasis) quality control of aggregated proteins in the cell to prevent the formation of toxic aggregates or what might also be called non-functional aggregated proteins arising from aberrant cellular processing

444 Notably, the metabolic signatures of senescent cells have been intensively investigated, with some typical changes in immunometabolism during ageing discussed below

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Groups of heads were then homogenized in Lysis Binding Mix (from MagMAX mir Vana Total RNA Isolation Kit

doi: 10.1038/icb.1996.32