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As such, lipid-lowering agents have become a mainstay of therapy in the primary and secondary prevention of major adverse cardiovascular events (MACE) [28,29,30,31]

10.1016/j.neuint.2012.04.008 [DOI] [PubMed] [Google Scholar] 104.Bradley K, Alonso C, Mehra L, Xu J, Gabbay V

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Am J Med Genet 1999;87:366-8

124 It is clear that not all patients will benefit from extended therapy judging from the results of the trial in which randomization to 48 or 72 weeks of therapy occurred at baseline

Accordingly, prominent sex differences exist in oxidative stress, as females are proposed to have overall lower levels of ROS-induced damage, reduced mitochondrial DNA damage, and higher antioxidant enzyme levels, thus being less vulnerable to oxidative insults than males (246, 249, 256)