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Between its constituents, melittin is the most prevalent and researched constituent of BV, after which comes PLA2, an enzyme that is regarded (along with histamine) as the primary allergen of BV

One hypothesis is that we observed a greater induction of NRF2 through liver-specific Gclc deletion as compared to KEAP1 inhibition with CDDO-me because CDDO-me is a weaker inhibitor of NRF2-KEAP1 interaction compared to the ROS generated following GSH depletion

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