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M9a + sh EPAS1 cells attenuate inflammation by enhancing mitophagy under hypoxia To investigate the mechanism of Tibetan adaptation to hypoxia, RNA sequencing was performed on three cell lines (M7/8+shCTR, M9a+shCTR, M9a+sh EPAS1 )

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*Correspondence: Chi Wang Ip, [email protected] This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Search strategy, inclusion criteria, and data extraction A systematic literature review was performed to characterize patients, interventions, comparisons, and outcome strategies