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Description
Front Endocrinol (Lausanne) 15:1443301

This indirect feedback system allows integration of both gonadal steroid negative feedback, coupled with signals of reproductive seasonie daylength, stress, nutritional and immune status, and is thought to couple puberty with growth and nutrition in humans

Plasma levels of TMAO are reportedly positively associated with cardiovascular risk and mortality in a dose-dependent manner ( Table 1 The negative effects of TMAO on atherosclerosis demonstrated via clinical and non-clinical experiments

2012 Cheng, AM

Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcn-Braga EA, Al-Kassab-Crdova A et al (2023) Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis

It is most concentrated in tissues that use fatty acids as their primary fuel, such as skeletal and cardiac muscle