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The following data were extracted from the interventional studies: authors names and year of publication, study design and washout time, dosage, substance and intervention duration, number, sex and age of participants, sport level and cognitive aspects which were assessed

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LSU genes) were not present in our results

For first-line drugs, isoniazid (INH) resistance is primarily associated with mutations in the katG gene, which encodes the catalase-peroxidase enzyme responsible for activating INH (Rivire et al., 2020)

Paxinos, G
It is important to note that PD and ED are linked by multiple mechanisms
