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In glioblastoma, proteomic results suggest that IGFBP-1 is a key mediator of cancer cell secretion in response to the vascular production-promoting factor macrophage colony-stimulating factor (MCSF)
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Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy
Combining them doubles GI side effects (nausea, gastroparesis risk) with no additional benefit
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