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A notable finding from CagriSema trials: the GI side effect profile of the combination was similar to semaglutide monotherapy , not meaningfully worse

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No, cagrilintide works differently because it is an amylin receptor agonist, while semaglutide and tirzepatide target GLP-1 receptors

Carbonation may increase gastric distension and potentially worsen bloating or discomfort in susceptible individuals

P =.172)

Early phase 2 clinical data, including a 2023 publication in the New England Journal of Medicine , suggest retatrutide may produce substantial weight loss