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It is also reported that L-carnitine supplementation can improve the glycemic status and related indices by changing the expression of genes related to glycolytic and gluconeogenic enzymes, modulating the activity of the pyruvate dehydrogenase enzyme complex, and changing the expression of genes involved in insulin metabolism (94, 95)

DOI Scopus10 WoS9 Europe PMC6 2014 Dunning, K., Anastasi, M., Zhang, V., Russell, D., & Robker, R

J Biol Chem 270:2480524809 Kanamori K, Parivar F, Ross BD (1993) A 15 N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats

L-Carnitin ist eine Aminosure-Verbindung, die in der Leber gebildet wird und entscheidend fr den Energiestoffwechsel ist, da sie Fettsuren in die Mitochondrien der Zellen transportiert

Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA