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Rather, the majority of orally ingested l-carnitine in mice produced a previously unappreciated intermediary metabolite, -butyrobetaine (BB), in a gut microbiotadependent step that occurred at a site anatomically proximal to, and at a rate 1,000-fold higher than the rate of the formation of TMA (26)

2005;288(4):F823-831

Serial block face scanning electron microscopy Two-month-old mice were anaesthetized using Avertin (0.5 mg g 1 ) and perfused with 4% paraformaldehyde