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After a few years, the seal around the door may not be as sealing as it once was
The titration schedule (increasing the dose every 4 weeks) is designed to be a long-term protocol
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When autophagy deficiency occurs, transmission electron microscopy shows the accumulation of LDs in IFT20KD cells, suggesting that T cell autophagy requires IFT20 and that the intraflagellar transporter IFT20 controls lysosomal biogenesis by regulating Golgi posttransport of acidic hydrolases (Finetti et al., 2020)
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