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7Of XA3%
Mechanistically, HHcy has been shown to impair mitochondrial electron transport chain efficiency, increase ROS and iron levels, and deplete intracellular GSH, thereby predisposing cells to ferroptosis [73,74]
Cut offs to separate cells with signal from background were determined using change point analysis 83
This combination of direct fat cell targeting, muscle preservation, metabolic selectivity, and favorable safety profile makes AOD-9604 a distinctive option among metabolic peptides and body composition interventions
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Menndez SG, Manucha W
