conservation of glutathione s-transferases S-Transferase - an overview Simplified scheme of action of

You guessed it, acetaminophen (Tylenol)

Verkhratsky A, Butt A, Li B, Illes P, Zorec R, Semyanov A, et al

This preventative role of GSTs in tumorigenesis is due to the mitigation of DNA damage caused by xenobiotics, carcinogens, and oxidation that could otherwise cause oncogenic mutations if not for the detoxification and peroxidase activities of this family of enzymes

doi: 10.1186/s41021-023-00278-1 218 WangB.QiuY.XieM.HuangP.YuY.SunQ.et al

It is a tightly regulated reaction that depends on both the availability of the amino acids (cysteine, glycine, and glutamate) and the rate-limiting enzyme, glutamate-cysteine ligase ( GCL )

This modification, known as an omega-amino acid modification, may help improve the peptides resistance to enzymatic degradation