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The reaction of H(2)S with oxidized thiols: generation of persulfides and implications to H(2)S biology

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GPX4-independent ferroptosisa new strategy in diseases therapy

[DOI] [PubMed] [Google Scholar] 407.Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Wu MS, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, and Hsieh CY

In the existing study, AZA treatment showed a significant depletion in the activity of hepatic GPx, SOD, and an insignificant reduction in CAT with a highly significant elevation in hepatic MDA level, which exerted severe oxidative stress induced by AZA that proved liver injury