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Long-term consequences of severe thiamine deficiency are manifested by the appearance of hemorrhagic and/or necrotic lesions with neuronal and dendritic spine loss in the thalamus, hypothalamus, and cerebellum (109111), as well as polyneuritis, peripheral edema, cardiac enlargement, and ophthalmoplegia ( When early, generalized thiamine deficiency is suspected, prompt administration of thiamine is advised and typically an effective treatment

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Urolithin production and metabotypes The presence of urolithins in the urine confirmed that the pomegranate extract reached the colon and underwent microbial metabolism to ellagic acid metabolites (Supplementary Figures 1, 2)

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Rhodiola is an adaptogen, increasing the bodys ability to adapt to the stress of physical exercise

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