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The Short Answer (And Why It's Not So Simple) Let's get this out of the way immediately

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doi: 10.1111/jpn.13049 166

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In severe acute pancreatitis (SAP), inflammatory factors promote the expression of matrix metalloproteinases (MMPs) and heparinases, which degrade syndecan-1 (SDC-1) and HS, while oxidative stress disrupts HA-CD44 binding, leading to increased capillary leakage and neutrophil adhesion

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