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In the first step, enzymes such as cytochrome P450 monooxygenases catalyze various reactions (oxidation, reduction or hydrolysis) to expose or introduce a functional moiety on hydrophobic substrates

This, however, remains to be carefully evaluated, as is the case for NMDA receptors

An Enzyme from Rat Liver Catalysing Conjugations with Glutathione

87 Their larger surface area and higher free energy enable them to remain stable against sedimentation, flocculation, coalescence, and creaming

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