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The progressive degeneration or dysfunction of RPE cells, which is a hallmark of multiple retinal disorders, invariably causes vision loss or even permanent blindness due to the absence of regenerative capacity (80) ( Table 1 )

This pathway is engaged when CASP8 activity is inhibited downstream of death receptors, such as TNF receptor superfamily member 1A (TNFRSF1A)

doi: 10.3389/fphar.2026.1767206 Received 14 December 2025 Revised 01 June 2026 Accepted 08 June 2026 Published 30 June 2026 Volume 17 - 2026 Edited by Nidhi Jalan-Sakrikar, Mayo Clinic, United States Reviewed by Slaan Pavlovi, University of Belgrade, Serbia Uro akar, University of Belgrade, Serbia Seddik Hammad, Heidelberg University, Germany Updates Copyright 2026 Philips, Sreemohan, Baby, Theruvath, Oommen, Ahamed, Tharakan and Augustine

These formulations include a variety of flours and additives, as well as enzymatic and microbial modifications that improve the food's rheological, functional, and sensory characteristics while reducing the gluten and GI content

As more human clinical trials are conducted, we will have a better idea of Epitalons potential