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Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (Table 2

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R.2000Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype.164(October 2000),297306,1059-7794 58

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Breitschwerdt and Kordick 2000) and it has been associated with a number of diseases in humans as well as administration of anabolic steroids and oral contraceptives (Naeim, Cooper, and Semion 1973
A novel and simple approach for extraction and isolation of curcuminoids from turmeric rhizomes
