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[DOI] [PMC free article] [PubMed] [Google Scholar] 253.Reimer R.A., Darimont C., Gremlich S., Nicolas-Metral V., Ruegg U.T., Mace K

Consequently, individuals in a state of decreased basal dopamine signaling, known as a hypodopaminergic state, may possess a greater risk for post-GLP-1RA treatment-associated psychiatric conditions such as depression and suicide, where polymorphisms in the DRD2 receptor are likely implicated in this pathophysiology [160,161]

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Participants titrating up to the highest dose of 36 milligrams lost an average of 12.4% of their initial body weight (27.3 pounds) over the course of the 72-week study

Laboratory studies have also shown that GLP-1 receptor activation can reduce reward-seeking behaviors in models exposed to drugs or highly palatable foods, supporting the biological plausibility of these observations (2 Trusted Source The glucagon-like peptide-1 analogue exendin-4 decreases the rewarding value of food and drug rewards