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Because of its MC1R / pigment effects, there are specific concerns about the darkening of moles and the need to monitor for melanoma

Patches stay on skin surface only

Until formal regulatory guidance is established, any use of therapeutic peptides must be supported by rigorous patient consent protocols, proper sourcing from 503B facilities, and continued outcome tracking

doi: 10.3390/biom10010056

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Relative to baseline, neuropathic pain grading scores improved in patients who were given intravenous B12, but not to a statistically significant degree [14]