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Inducible expression of the -glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element

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In this regard, utilizing more representative larger animal models (e.g., non-human primates, swine, ferrets) in parallel with rodents for intranasal delivery research could improve the predictive value of preclinical studies

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It has been shown that GSTT1 expression is significantly upregulated in chemotherapy-resistant serous ovarian cancer (SOC) cells and that inhibition of GSTT1 expression negatively influenced the proliferation of SOC cells, thereby enhancing their sensitivity to paclitaxel/carboplatin [116]

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