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Thus, albeit initially the concerns on the use PDE5i for CAD treatment - due to the marginal beneficial effects - shifted their application from CVD to ED, thereafter, sildenafil was reallocated for the treatment of cardiac disorders, due to both endothelial and anti-inflammatory/pro-remodeling effects in cardiac cells (43)

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B12 plays a key role in maintaining the myelin sheath that protects nerves so problems like tingling or numbness in the face can happen
