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Nonetheless, 3DVA of CTR complexes bound to either Cagri or CagriBB revealed transitions between the two major alternative conformations (Supplementary Fig

The elevated homocysteine creates further oxidative stress and neuroinflammation, which in turn damages the myelin sheath and worsens the cognitive dysfunction and neuropathy

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The important caveat is that all of them come from in vitro cell studies or animal models not human beings