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Collectively, our observations indicate that GCLM KO mice exhibit hepatic and systemic oxidative stress

Mitochondrial glutathione depletion directly correlates with oxidative damage to mitochondrial DNA, which accumulates during aging and impairs respiratory chain function

Manassas, VA, USA) and were maintained in RPMI 1640 medium (Pan-Biotech, Aidenbach, Germany) supplemented with 10% FBS (Gibco, Waltham, MA, USA) and 1% penicillinstreptomycin (Gibco) at 37 C, 5% CO 2

2C, D and Supplementary Fig

Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial