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Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis

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When wounded, Nrf2 / mice have been shown to display delayed healing and prolonged inflammation in the affected area, with expression of proinflammatory cytokines altered such that although their expression levels are lower than those of wild-type mice their production continues for a significantly longer time period [94]

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Besides, iron accumulation can directly polarize macrophages to pro-inflammatory profile (61), promote pro-inflammatory cytokine secretion to induce autoimmune diseases ( via pro-inflammatory change (62)

If symptoms suggest deficiency but serum B12 looks normal, ask for a methylmalonic acid (MMA) test it detects cellular deficiency earlier