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DOI: 10.4103/1673-5374.320969

Mitochondrial dysfunction and oxidative stress are often implicated in progressive neurodegenerative disorders such Alzheimers disease and Parkinsons disease and in damage secondary to TBI.5,6 Additionally, new research both in vitro and in mice has suggests that methylene blue may reduce neuronal apoptosis and improve blood-brain barrier integrity.7 One randomized, blinded, placebo-controlled trial evaluated the effects of methylene blue 10mg/kg administered intraperitonially to mice and rats immediately or 24 hours post ischemic stroke

Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis

Importantly, clinical evidence in humans remains extremely limited, meaning that promising animal results should be interpreted cautiously until validated in well-controlled trials