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Protein considerations: Adequate protein intake is essential during semaglutide treatment to preserve lean mass, but very high protein diets can make urine more acidic and concentrated

This is referred to as an obesogenic diet (Ikemoto et al., 1996)

In the brain, both GIP and GLP1 are thought to be involved in memory formation as well as the control of appetite

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Half will get tablets containing semaglutide and half will get inactive placebo tablets (which look like the semaglutide tablets but have no active drug in them)

For a broader overview of GI symptoms, see our article on GLP-1 side effects in 2026