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This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

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When combined with hyaluronic acid, the results were even more significant surpassing either treatment used alone.[5] While human joint trials are still lacking, this is a promising area of investigation, particularly for patients dealing with both excess weight and degenerative joint conditions