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Trends Cancer 4 , 151165 (2018)

The Phase 2 clinical trial in postoperative-ileus patients used intravenous administration (PMID 25331030)
278 These pathways lead to granzyme release, ROS production, 279 and the activation of transcription factors, including STAT3, 280 NF-B, activator protein 1 (AP-1), 281 and cAMP-responsive element-binding protein (CREB), 277 which further contributes to the expression of pro-inflammatory cytokines, co-stimulatory molecules, and complement components

Despite the developments in ML, the interpretability of complex models and the need for validation in various patient populations pose challenges

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