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Studies have consistently reported that inhibiting NNMT activity or downregulating NNMT expression leads to significant increases in NAD + levels in mouse adipocytes (Neelakantan et al., 2018) and hepatocytes (Song et al., 2020)

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10.3389/fpls.2022.1006044 [DOI] [PMC free article] [PubMed] [Google Scholar] Shanks CM, Rothkegel K, Brooks MD, Cheng C-Y, Alvarez JM, Ruffel S, Krouk G, Gutirrez RA, Coruzzi GM

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