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Parthenolide is a partial agonist at the TRPA1 channel, desensitizes the channel (Materazzi et al., 2013), and is an active constituent of the feverfew plant, a natural remedy used for headaches (Cady et al., 2011)

This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin which causes deficiency

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In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

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The selectivity of AOD-9604 makes it particularly suitable for combination protocols because it targets one specific pathway without disrupting others