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The FDA recommends Semaglutide for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes or high cholesterol Have a BMI of 30kg/m2 or greater Avoid semaglutide if you have: History of medullary thyroid cancer History of gallbladder disease History of pancreatitis Multiple endocrine neoplasia syndrome type 2 (MEN2) If youre considering semaglutide for weight loss, your first step should be consulting your primary care physician (PCP)