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That starts with bloodwork
Extracellular vesicles: A new frontier in biomarker discovery for non-alcoholic fatty liver disease
doi: 10.3389/fnhum.2020.602360 122
Thus, to infer the activity of a specific metabolic pathway, UHPLC-MS needs to be accompanied by other metabolic assays
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doi: 10.1113/jp275588 40 Corb AronR
