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In contrast, whether the unstable gut-derived GLP-1 directly acts on pancreatic -cells remains controversial [58]

On the other hand, a meta-analysis of randomized clinical trials and a systematic review of observational studies reported no increased risk of pancreatitis or pancreatic cancer in patients treated with GLP1RA [86,87]

During the initial weeks of combined therapy, healthcare providers typically monitor blood sugar levels closely and adjust insulin doses as needed

You can also incorporate more movement into your daily routine by walking your dog, cleaning the house, or choosing stairs over elevators

Additionally, some atypical antipsychotics used for treatment-resistant depression (such as quetiapine or olanzapine) carry a high risk of metabolic syndrome, weight gain, and hyperglycaemia, as noted in NICE guidance