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Semaglutide's GLP-1 mechanism produces glucose-dependent insulin secretion alongside glucagon suppression, a profile characterised across the SUSTAIN program of clinical trials in type 2 diabetes anchored by the 2017 Sorli SUSTAIN-1 paper (PMID 28110911)

Park EY, Shimura N, Konishi T, et al

Cancer Res 2013;73:1662-7
