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The requirement of two distinct glutathione interaction sites for the efficient reduction of GSSR by GSH explains the deviating properties and substrate preferences of glutaredoxin subfamilies as well as thioredoxins with implications for the design and optimization of artificial enzymes and inhibitors

Consistently, given the close BPC 157/NO-system relations (see Chapter NO), these should be overseen with the evidence that the gasotransmitters can cross the cell membrane and act directly on molecules inside the cell [36], and thereby, particularly interacting with receptors on the plasma membrane of their target cells can be envisaged