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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Schmitt B., Vicenzi M., Garrel C., Denis F.M
More recently, thioredoxin itself has been shown to be subject to reversible glutathionylation [35]
Glutathione adducts have also been characterized for the opiate agonist oxycodone and its antagonist, naltrexone [43] as well as for pharmacologically unrelated drugs such as acetaminophen [44,45], cocaine [46], methylenedioxymethamphetamine (MDMA) [47], and 9-tetrahydrocannabinol (THC) [43]
MUFA: mono-unsaturated fatty acid
This is because the various forms of glutathione have targeted benefits
These experiments indicated that, in addition to requiring Cys-dependent de novo biosynthesis of GSH for survival (see above), TrxR1/Gsr-null livers require de novo biosynthesis of Cys via transsulfuration, and that they cannot effectively utilize cystine as a hepatic Cys source [107]
