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Furthermore, western blot was used to analyze the protein levels of representative senescent markers, including p16, p21, and p53

The FDA's Category 2 designation means the substance may present significant safety risks when used in compounding and is prohibited in compounded medications pending further evaluation

Disruption of this coordination, whether through mitochondrial dysfunction leading to decreased CPT1 activity or insufficient substrate supply for FAO, can cause energy imbalance in the myocardium

p = not significant in intergroup analysis)

Their core value lies in synergizing with conventional treatments to enhance efficacy and reduce adverse effects, addressing unmet needs in ADs such as long-term remission maintenance and slowing early disease progression, without replacing core first-line therapies

however, it also induced several local adverse effects on dorsal skin, including skin thinning with atrophy and hypertrichosis