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Mechanistic insights from non-AD neuroinflammatory systems provide complementary evidence: interferon- (IFN-) robustly induces PD-L1 expression in human astrocytes and microglia, establishing a checkpointredox interface that suppresses excessive oxidative injury (Smith et al., 2023

Studies have shown that total meniscectomy leads to a substantially higher risk of OA progression compared to partial meniscectomy, with increased incidence of joint space narrowing and osteophyte formation (Ma X

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Cell 77 , 10551065.e1054 (2020)

Due to the genetic variability, one therapeutic approach may not fit all patients