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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

PMID 17524376

Gene expression analysis in ARPE-19 cells was conducted by amplifying the following genes: SOD2 (protein name: superoxide dismutase 2, mitochondrial), CAT (protein name: catalase), HMOX1 (protein name: heme oxygenase 1), SNAL1 (protein name: Snail Family Transcriptional Repressor 1), ZEB1 (protein name: Zinc finger E-box-binding homeobox 1), TWIST1 (protein name: Twist Family BHLH Transcription Factor 1), VIM (protein name: Vimentin), FN1 (protein name: Fibronectin 1), ACTA2 (protein name: actin alpha 2, smooth muscle) and GAPDH (protein name: glyceraldehyde-3-phosphate dehydrogenase)

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ADHD (clonidine extended-release) Clonidine stimulates presynaptic -2 (-2A) receptors in the prefrontal cortex, resulting in reduced release of norepinephrine

Synaptogenic effects appear particularly pronounced