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2024;13(7):881.[DOI] 180

MTHFD1 G1958A polymorphism is described as a risk factor for head and neck cancer development [163]

In vivo testing in xenograft mouse models confirmed that UCM 1037 suppressed DX3 tumor growth and demonstrated greater inhibitory activity compared to melatonin alone at the same dose (16 mg/kg) [87]

During oxidative stress, Keap1 undergoes modifications that inhibit its interaction with Nrf2, allowing Nrf2 to accumulate and activate the expression of antioxidant and cytoprotective genes

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