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The CYP2E1 induced increases oxidative stress in the hepatocytes, activates fibrotic signals by enhancing proliferation of stellate cells and increases collagen type 1 protein [83]

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Nat Rev Mol Cell Biol 5(5):343354 Semenza G (2011) Mechanisms of disease oxygen sensing, homeostasis, and disease (vol 365, pg 537, 2011)

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Prss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, et al

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