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Using siRNAs, we specifically knocked down mRNA expression of each of these (Figure 6C)

Additionally, in a trial of LC in the treatment of chronic fatigue syndrome, eight patients dropped out because they could not tolerate the excessive stimulation and insomnia after the intervention [42]

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Therefore, successful translation will depend on advances in targeted CNS delivery systems and a thorough understanding of the temporal dynamics of microglial activation in tinnitus pathogenesis

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